Table 3.
Effects of extended-release niacin and a combination of extended-release niacin and lovastatin, relative to placebo, on apoA-I-containing HDL subpopulation concentrations in the non-fasting state.
| Placebo | Niacin | Niacin+Lovastatin | |
|---|---|---|---|
| preβ1 | 18.1±5.5 | 16.3±5.4 | 18.5±5.8 |
| preβ2 | 2.7±1.1 | 3.0±1.0 | 3.2±1.6 |
| α1 | 7.1±3.5 | 14.1±5.9* | 13.5±3.7* |
| α2 | 27.0±5.6 | 33.5±2.2† | 36.9±4.1* |
| α3 | 25.4±5.9 | 22.5±6.9 | 21.5±4.2 |
| α4 | 11.8±1.7 | 10.2±2.0 | 9.1±0.7 |
| preα1 | 2.4±2.1 | 7.8±5.1† | 6.0±3.1 |
| preα2 | 4.1±1.0 | 6.8±2.1† | 6.6±2.0† |
| preα3 | 2.9±0.9 | 2.8±0.7 | 2.6±0.3 |
| preα4 | 1.5±0.6 | 1.3±0.4 | 1.3±0.2 |
| CETP | 0.98±0.15 | 0.91±0.31 | 0.78±0.19 |
| LCAT | 11.0±1.5 | 9.6±1.5 | 10.2±1.8 |
HDL subpopulations expressed as mg/dL of apoA-I; CETP and LCAT mass expressed as μg/ml Values are mean±SD;
P<0.01 vs placebo;
P<0.03 vs placebo