. Author manuscript; available in PMC: 2009 Oct 14.

Published in final edited form as: Cancer Gene Ther. 2008 Apr 11;15(7):413–448. doi: 10.1038/cgt.2008.15

Table 10.

Possible approaches for therapeutic targeting of ERBB3

	References
Experimental approaches under study
RNA aptamers to extracellular domain (breast cancer cells)	431
Synthetic designer zinc finger transcription factor (squamous carcinoma cells)	432
Vitamin E isomer (breast cancer cells)	433
Micro-RNA downregulation of mRNA (breast cancer cells)	434
siRNA downregulation of mRNA (lung cancer cells)	Table 9
Suggested approaches
NRDP1 ubiquitin ligase as negative regulator	435
Blockage of transactivation	436
Blockage of NRG nucleocytoplasmic trafficking	437
Specific inhibitor of ADAM17 sheddase	425,426