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. 2009 Jul 8;29(27):8655–8668. doi: 10.1523/JNEUROSCI.5900-08.2009

Figure 8.

Figure 8.

Line differences in NAC Homer2 and PI3K activity in selectively bred SHAC and SLAC mice. a, b, Summary of the average alcohol dose consumed (grams per kilogram; a) and BACs (b) attained after the second session of 30 min alcohol drinking (selection phenotype) in the genetically heterogeneous HS/Npt mice (foundation population for the selection) and in the SHAC and SHAC offspring, across four generations of selective breeding. Data in a and b represent the mean ± SEM of 80–104 mice per line per generation; *p < 0.05, SHAC offspring versus SLAC offspring. c, Representative immunoblots for the total protein levels of Homer2a/b, Homer1b/c, mGluR1, mGluR5, NR2a, NR2b, PI3K, p(Tyr)p85α PI3K binding motif [p(Try)p85α], and calnexin (loading control) in the NAC of fourth generation (S4) selectively bred SHAC and SLAC mice, at 3 months after their second 30 min alcohol-drinking session. d, Summary of the line differences in protein expression, expressed as a percentage of average levels of SLAC animals. Data in d represent the mean ± SEM of the number of mice indicated in the figure. *p < 0.05 versus SLAC (t tests).