Fig. 1. The duration of the elevation in thermal (radiant heat) response latency (A) and mechanical threshold (von Frey) (B) produced by intraplantar injection of a combination of QX-314 together with lidocaine (0.2% QX-314, 1% lidocaine, 10 μl) exceeds that produced by lidocaine alone (1%, 10 μl). QX-314 alone did not alter mechanical or thermal responsiveness (0.2%, 10 μl). Arrows indicate the cutoffs, and the dotted line indicates baseline level (mean ± SEM; * P < 0.05, ANOVA followed by Dunnett's test; n = 6 for each group).