Figure 1.

Nerve injury upregulates Best1 expression. A, RT-PCR analysis of candidate genes for Ca⁺-activated Cl⁻ current in L4–L5 dorsal root ganglia 5 d after sciatic nerve section. B, qRT-PCR analysis of bestrophin-1, -3, Tmem16a and Tmem16b transcripts in lumbar L4–L5 DRG show a significant increase in Best1 transcripts after peripheral nerve injury (n = 4; ***p < 0.001, ANOVA with Bonferroni post hoc test). C, In situ hybridization of Best1 on normal and axotomized adult DRG (scale bar, 50 μm).