Figure 1.

(A–C) Northern blot analyses of RSOR in kidneys of control (NM) and DM. RSOR is up-regulated in DM kidneys (A). The β-actin expression is unaffected (C). B is the same blot stained with methylene blue, and it shows intactness of the RNAs and their loading of equal amounts in various lanes. (D) Alignment of the amino acid sequences of mouse, rat, and human RSOR. Dots indicate the identity of the amino acids. Mouse RSOR has ≈97% and ≈91% sequence homology with rat and human forms, respectively. Arrows indicate N and C terminals of the RSOR. * indicates glycosylation site. MAKSKDSFRNYTSGPL, AKR motif.