Table 2.1.

Terminology

Symbol	Definition	Unit
I	Ionic strength	M
Ka,l	Dissociation constant for the lth protonation reaction	M
pKal	−log10 (Ka,l/c0)	Dimensionless
KM,m	Dissociation constant for metabolite binding to metal M	M
pKaM,m	−log10 (KM,m/c0)	Dimensionless
c0	Reference concentration for all species (1 M)	M
Pi	Binding polynomial for ith metabolite	Dimensionless
${\overline{N}}_H^i$	Average proton binding of ith metabolite at specified T, P, pH, pMg, and I	Dimensionless, noninteger
nk	Proton generation stoichiometry of the kth reference reaction	Dimensionless
${\mathrm{\Delta }}_r{N}_H^k$	Proton generation stoichiometry of the kth biochemical reaction at specified T, P, pH, pMg, and I	Dimensionless, noninteger
NH(j)	Number of H atoms in species j	Dimensionless, integer
zj	Charge on species j	Dimensionless, integer
${\mathrm{\Delta }}_f{G}_j^0(I=0)$	Gibbs energy of formation at zero ionic strength of species j	kJ/mol
$v_j^k$	Stoichiometric coefficient of species j in the kth reference reaction
$K_{\mathit{ref}}^k$	Equilibrium constant of kth reference reaction	Dimensionless
${\mathrm{\Delta }}_r{G}_k^0$	Standard free energy of kth reference reaction	kJ/mol
$K_{\mathit{app}}^k$	Apparent equilibrium constant of kth biochemical reaction	Dimensionless
${\mathrm{\Delta }}_r{G^{\prime }}_k^0$	Standard free energy of kth biochemical reaction	kJ/mol
ΔrGk	Free energy span of kth biochemical reaction	kJ/mol
${\mathrm{\Delta }}_r{H}_j^0$	Standard Enthalpy of jth proton dissociation reaction at a given ionic strength	kJ/mol
$J_r^k$	Flux through reaction kth biochemical reaction	M/min
[Li]	Concentration of biochemical reactant i	M