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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Arch Neurol. 2009 Oct;66(10):1247–1253. doi: 10.1001/archneurol.2009.207

Table 3.

Mean Differences (95% CI) in Cognitive Decline, per Standard Deviation of Amyloid β Measures at Mid-life*

COGNITIVE TEST TICS GLOBAL SCORE VERBAL SCORE
Amyloid β 40:42 Ratio
    Age/education-adjusted −0.07 (−0.14, −0.00) −0.02 (−0.04, −0.00) −0.02 (−0.04, 0.00)
    p-trend 0.05 0.02 0.08
    Multivariable-adjusted −0.07 (−0.14, 0.00) −0.02 (−0.04, −0.00) −0.02 (−0.04, 0.01)
    p-trend 0.07 0.04 0.16
Amyloid β 42
    Age/education-adjusted −0.01 (−0.08, 0.07) 0.00 (−0.02, 0.02) −0.00 (−0.03, 0.02)
    p-trend 0.88 0.96 0.79
    Multivariable-adjusted −0.00 (−0.08, 0.07) 0.00 (−0.02, 0.02) −0.00 (−0.03, 0.02)
    p-trend 0.89 0.99 0.77
*

Models adjusted for age at baseline interview and education; cigarette smoking, postmenopausal hormone use, hypertension, elevated cholesterol, body mass index, alcohol intake and physical activity level as of blood draw; and depression status as of start of cognitive testing. Mean (range) testing interval was 4.1 (3.1 − 5.5) years.