Table 4.

Mean Differences (95% CI) in Cognitive Decline^*, by Percent Change over Ten Years in Plasma Amyloid β Measures

COGNITIVE TEST	TICS	GLOBAL SCORE	VERBAL SCORE
Amyloid β 40:42 Ratio
Age/education-adjusted	−0.08 (−0.15, −0.01)	−0.02 (−0.04, −0.00)	−0.02 (−0.04, 0.01)
p-trend†	0.02	0.03	0.16
Multivariable-adjusted‡	−0.08 (−0.15, −0.01)	−0.02 (−0.04, −0.00)	−0.02 (−0.04, 0.01)
p-trend†	0.02	0.03	0.18
Amyloid β 42
Age/education-adjusted	0.03 (−0.03, 0.10)	0.01 (−0.01, 0.02)	−0.00 (−0.03, 0.02)
p-trend†	0.32	0.56	0.67
Multivariable-adjusted‡	0.04 (−0.03, 0.11)	0.01 (−0.01, 0.02)	−0.01 (−0.03, 0.02)
p-trend†	0.31	0.57	0.65

^*Mean (range) cognitive testing interval was 4.1 (3.1 − 5.5) years.

^†Linear trend for each SD increase in percent change of Aβ−40:Aβ−42 ratio or Aβ−42. Mean (range) interval between first and second plasma collection was 11.1 (9.2 − 12.2) years.

^‡Models adjusted for age at baseline interview and education; cigarette smoking, postmenopausal hormone use, hypertension, elevated cholesterol, body mass index, alcohol intake and physical activity level as of blood draw; and depression status as of start of cognitive testing.