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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Neuroscience. 2009 Aug 28;164(2):478–487. doi: 10.1016/j.neuroscience.2009.08.049

Table 2.

Expression of potential neuronal guidance receptors in the adult cochlea

Gene Symbola mRNA Levelb Other Reportsc Gene Symbol mRNA Level Other Reports Gene Symbol mRNA Level Other Reports
Ephrin Pathway Semaphorin Pathway Netrin Pathway
Efna1 5.2±0.4 i, ii Nrp1 8.5±1.0* i Dcc 6.3±0.4* i, vi
Efna2 5.6±1.3 i, ii, iii Nrp2 8.0±0.1* Unc5a 5.8±0.6
Efna5 7.5±0.5* i Plxna1 6.9±0.7* Unc5b 6.1±1.2
Efnb1 7.9±0.3* i, iii Plxna2 7.3±0.4* Unc5c 7.4±0.4* i
Efnb2 8.0±1.5* iv, v Plxna3 5.7±0.7 i Unc5d 7.1±1.5*
Efnb3 5.8±0.4* v, Plxna4 5.9±0.4*
Epha2 6.9±0.4* Plxnb1 6.0±0.5* Wnt Pathway
Epha4 6.0±2.5 i, ii, iii Plxnb2 7.5±1.5* i Fzd1 8.3±0.7* vii
Epha5 6.3±0.5* ii Plxnb3 6.6±1.3 Fzd2 7.5±1.2* i, vii
Epha7 6.6±0.4* i, ii Plxnc1 7.0±0.8* Fzd3 5.9±0.7 vii
Epha8 5.2±0.7 Plxnd1 6.7±0.9* i Fzd4 6.0±0.9 i, vii
Epha10 6.5±0.5* Sema4d 8.0±0.6* Fzd5 5.7±0.6
Ephb1 6.2±0.3* iii, v Sema4f 6.5±0.7* Fzd6 7.6±1.1* vii
Ephb2 6.6±0.9* i, v Sema5a 7.0±0.9* Fzd7 7.9±1.1*
Ephb3 6.3±0.5* i, iv, v Sema6a 5.8±0.3* Fzd8 5.7±0.7 i
Ephb4 6.4±0.4* Fzd9 7.0±0.6* i, vii
Ephb6 5.6±0.4 Slit Pathway Fzd10 6.5±0.5*
Robo1 5.5±2.7 Lrp6 5.1±0.2
Robo4 5.7±0.4* i Ror1 5.2±0.5
Ryk 7.4±0.5*
a

Efn…, ephrins; Eph…, Eph receptors; Nrp…, neuropilins; Plxn…, plexins; Sema…, semaphorins; Robo…, roundabout homologs; Dcc…, deleted in colorectal carcinoma; Unc…, unc-5 homologs; Lrp6, low density lipoprotein receptor-related protein 6; Ror…, receptor tyrosine kinase-like orphan receptor.

b

Mean ± SD (n = 17) of log2-transformed and pre-processed microarray hybridization signals in GEO entries GSM321743-8 (modioli of 8-week-old CBA/CaJ mice; this study), GSM108103-8 (4- and 15-month-old C57BL/6 mice; Someya et al., 2007), and GSM109462-6 (9-month-old C57BL/6 mice; Someya et al., 2008).

c

i, CBA/CaJ mice at P32 (Chen and Corey, 2002); ii, 2- to 4-month-old mongolian gerbils (Bianchi and Liu, 1999); iii, 4- to 34-month-old mongolian gerbils (Bianchi and Gale, 1998); iv, adult mice (Bianchi et al., 2002); v, adult CD-1 mice (Howard et al., 2003); vi, C57 mice at P28 to P35 (Lee and Warchol, 2008); vii, Wistar rats at P14 (Daudet et al., 2002).

*

Significantly above 44th-percentile cutoff of 5.10 in one-sided t tests with 1,369 probe sets for neuronal transmembrane receptors (P < 0.05 after Bonferroni correction).