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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Neuroscience. 2009 Aug 7;164(2):507–519. doi: 10.1016/j.neuroscience.2009.08.008

Figure 9. BDNF effects on the surface expression of the δ subunit were mediated through activation of PLCγ.

Figure 9

A- Surface expression of the δ subunit was studied in the slices treated with BDNF for 6 hr in the presence of PLC inhibitor U73122 (5 μM) or PI3K inhibitor LY294002 (5 μM). Increased surface expression (S) of the δ subunit by BDNF was blocked by U73122 but not by LY294002. Total expression (T) of the δ subunit was similar in all the samples. B- Surface expression of the δ subunit after treatment with BDNF or BDNF and inhibitors (n=3–5, * p<0.05). C- A representative blot shows surface (S) and total (T) expression of the δ subunit was unaltered in slices treated with U73122.