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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Hepatol. 2009 Feb 5;51(5):909–917. doi: 10.1016/j.jhep.2008.11.026

Fig. 6.

Fig. 6

Hepatic necrosis and malignant transformation in the AAV8-hG6PT-infused GSD-Ib mice. (A) H&E stained liver sections in the 52- and 72-week-old AAV8-hG6PT-infused GSD-Ib mice (−/−/AAV). Representative sections showed multiple necrotic foci at magnifications from left to right, ×50, ×200, and ×200. (B) H&E stained liver sections showing a poorly differentiated anaplatic carcinoma in the 52-week-old AAV8-hG6PT-infused GSD-Ib mice with HCA. Top panels, the composite pictures of the carcinoma stitched together using the Photomerge feature of Adobe Photoshop CS3 as described under Materials and Methods at a magnification of ×17; the 2 rows of lower panels, representative sections at a magnification of ×400.