Figure 1. Concentration-response curves for cocaine and cocaine methiodide.

Dopamine uptake by mouse DAT (A), norepinephrine uptake by mouse NET (B), and serotonin uptake by mouse SERT (C) into transfected cells were measured in the presence of increasing concentrations of cocaine or cocaine methiodide. The Na⁺ channel currents in isolated mouse DRG neurons were recorded by whole-cell patch clamping (D). The data are presented as the percent of the pre-drug activity. Dopamine uptake by striatal synaptosomes were measured in the presence of increasing concentrations of cocaine or cocaine methiodide (E). For A, B, C, and E, each data point represents the average of triplicate measurements ± standard error of means and the experiments were repeated three times with similar results. For D, each data point was obtained from four cells.