. Author manuscript; available in PMC: 2009 Oct 15.

Published in final edited form as: JAMA. 2008 Nov 26;300(20):2389–2397. doi: 10.1001/jama.2008.649

Table 5.

Cumulative 10-year mortality in 475 Joslin patients with type 2 diabetes according to degree of glycemic control before study entry and 9p21 genotype.

			Cumulative 10-Year Mortality
Group			All-Cause				CVD
rs2383206	HbA1c tertile^†	n	% (n)^§	95% CI	p^‡	p^¶	% (n)^§	95% CI	p^‡	p^¶
A/A + A/G	1^st + 2^nd	213	31.6 (64)	25.1–38.1			19.8 (37)	13.9–25.7
A/A + A/G	3^rd	106	30.0 (29)	20.8–39.2	0.78		20.1 (18)	11.7–28.5	0.95
G/G	1^st + 2^nd	107	23.1 (23)	14.7–31.5			15.3 (15)	8.0–22.6
G/G	3^rd	49	43.6 (19)	28.5–58.7	0.021	0.036	35.6 (14)	20.1–51.1	0.020	0.049

Follow-up was ≥ 10 years for 68.3% and ≥ 9 years for 84.5% of study subjects who were not deceased by December 31, 2004.

^†

3rd tertile boundary=8.9%.

^§

The numbers in parentheses are the numbers of deaths observed in each group. Percent mortalities and their confidence intervals were obtained by lifetable methods. Hence the percents do not exactly correspond to the number of deaths divided by the sample size.

^‡

3^rd vs. 1^st + 2^nd tertiles of HbA1c.

^¶

Interaction between HbA1c tertile group and rs2383206 genotype.