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Model for For3 localization and activation at the cell tips. Pob1 localizes to cell tips by binding to GTP-Cdc42, and in turn serves as a tether for For3 N terminus and facilitates the Cdc42-mediated relief of For3 autoinhibition. Bud6 binding at the C terminus of For3 similarly serves as both anchor and activator of the formin (Martin et al., 2007).
