Table 2.

SNPs in human NAT2 coding region

SNPa	rs identifierb	SNP500 Cancer IDc	Amino acid change	NAT2 allele/haplotype	Functional effectd
34T>C			Y12H
70T>A			L24I	NAT2*5L
111T>C		NAT2-20	F37F	NAT2*6D	Synonymous
190C>T	1805158	NAT2-03	R64W	NAT2*19	Decrease
191G>A	1801279	NAT2-04	R64Q	NAT1*14 cluster and others	Decrease
282C>T	1041983	NAT2-05	Y94Y	NAT2*13 cluster and others	Synonymous
341C>T	1801280	NAT2-06	I114T	NAT2*5 cluster	Decrease
345C>T			D115D	NAT2*6L	Synonymous
364G>A	4986996	NAT2-09	D112N	NAT2*12D	Decrease
403C>G	12720065	NAT2-19	L135V	NAT2*12H
411A>T	4986997	NAT2-10	L137F	NAT2*5I
434A>C			Q145P	NAT2*17	Decrease
472A>C			I158L
481C>T	1799929	NAT2-07	L161L	Many	Synonymous
499G>A			E167K	NAT2*10
518A>G			K173R
578C>T			T193M	NAT2*12E; *13B
589C>T			R197X
590G>A	1799930	NAT2-08	R197Q	NAT2*6 cluster and others	Decrease
609G>T			E203D	NAT2*12G
622T>C			Y208H	NAT2*12F
641C>T			T214I
683C>T			P228L	NAT2*14H
759C>T	56011192	NAT2-17	V253V	NAT2*5F	Synonymous
766A>G			K256E	NAT2*6H
803A>G	1208	NAT2-01	K268R	NAT2*12 cluster and others	No effect
809T>C			I270T
838G>A			V280M	NAT2*5M; *6I; *6K
845A>C	56054745	NAT2-18	K282T	NAT2*18	Substrate-dependent decrease
857G>A	1799931	NAT2-02	G286E	NAT2*7 cluster	Substrate-dependent decrease
859Del			S287frameshift	NAT2*11B

^aReference gene sequence published in Genbank Assession Number X14672. Most common SNPs are bolded. Adapted from http://N-acetyltransferasenomenclature.louisville.edu and [39,40].

^bNot all SNPs have been designated.

^cAccessed from http://snp500cancer.nci.nih.gov/snplist.cfm?gene_id=NAT2&mode=valid. This SNP nomenclature is distinct from the NAT2 allele (haplotype) nomenclature.

^dSNPs are non-synonymous unless otherwise indicated. Only functional effects supported with experimental data are provided.