Table 1.

Included Studies

STUDY NAME	N	PATIENT POPULATION	BRIEF DESCRIPTION	OUTCOME
Amantadine and Propranolol(Kampman et al., 2006) AMPRO	199	Cocaine dependent, alcohol co-dependence allowed if med-free detox	10-week double-blind trial with 4 groups; Amantadine 300 mg/day Propranolol 100 mg/day Amantadine + Propranolol Placebo	No overall significant effect of either drug alone or the combination. Among highly adherent patients, Propranolol had better retention and AB rates.
Naltrexone and Disulfiram(Pettinati et al., 2008) DISULF	208	Cocaine and alcohol dependence	14-week double-blind trial with 4 groups; Disulfiram 250 mg/day Naltrexone 100 mg/day Disulfiram + Naltrexone Placebo	Abstinence from cocaine as measured by cocaine-negative urines and days of self-reported abstinence from cocaine or alcohol did not differ between placebo and any of the medication groups