Table 1.
Gene Regulation in PBMCs from normal donors following 1hr IFN-α treatment in vitro
| Gene | Function | Fold Change Post vs Pre- treatment |
|---|---|---|
| Chemokine (C-X-C motif) ligand 10(CXCL10) | Chemotaxis, stimulates NK cells and monocytes | 176.1 |
| Chemokine (C-C motif) ligand 8(CCL8) | Chemotaxis | 122.3 |
| Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) | Immune response | 117.2 |
| Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) | Immune response | 62.2 |
| Sterile alpha motif domain containing 9-like (SAMD9L) | Unknown | 44.3 |
| LOC341720 | Unknown | 24.6 |
| Cholesterol 25-hydroxylase (CH25H) | Catalytic activity | 21.3 |
| Guanylate binding protein 1(GBP1) | Immune response | 13.9 |
| CD274 antigen (CD274) | Immune response, cell proliferation | 13.7 |
| Nuclear receptor coactivator 7(NCOA7) | Transcriptional regulation, nucleic acid metabolism | 8.5 |
| FLJ20968 | Unknown | 7.3 |
| Interferon induced with helicase C domain 1 (IFIH1) | Regulation of apoptosis, regulation of translation | 5.6 |
| FLJ11000 | Unknown | 4.5 |
| FLJ10159 | Unknown | 4.4 |
| EST sequence | Unknown | 4.3 |
| Caspase 4 (CASP4) | Induction of apoptosis | 3.9 |
| Interleukin 6 (IL6) | B cell and T cell differentiation | 3.6 |
| EST sequence | Unknown | 3.6 |
| Suppressor of cytokine signaling 2(SOCS2) | Inhibition of Jak/STAT signaling | 2.8 |
| EST sequence | Unknown | 2.5 |
| T-cell activation GTPase activating protein (TAGAP) | GTPase activator | 2.4 |
| ADP-ribosylation factor-like 8(ARL8) | GTPase | 2.1 |
Genes had a probe set differentially expressed by more than 2-fold (p < 0.001).