FIG. 2.

Polyclonal T cell proliferation with increasing viral load in subjects with T cell cytokine responses comparable to uninfected subjects. (A) Anti-CD3/CD28-mediated IFN-γ responses (following subtraction of the unstimulated levels, expressed as log pg/ml) in HIV-1⁻ subjects and in HIV-1⁺ subjects with plasma HIV-1 RNA <400, 400–5000, and >5000 copies/ml irrespective of ART status. (B) Anti-CD3/CD28 T cell responses (expressed as SI) in HIV-1⁺ subjects with plasma HIV-1 RNA <400, 400–5000, and >5000 copies/ml in the presence or absence of ART. (C) Percentages of CD8⁺/CD38⁺ T cells in HIV-1⁺ subjects in groups as summarized in (B). Dots represent individual patients data, while lines indicate the median and 25th and 75th percentiles. Significant p values are shown on the top of each graph.