Fig. 1.
Hierarchical cluster analysis of 314 genes included in the mouse TGF-β signature. Data are presented in a matrix format in which rows and columns represent genes and samples, respectively. Hepatocytes were isolated from Tgfbr2+/+/AlbCre+/− (WT, two left panels) and Tgfbr2fl/fl/AlbCre+/− (KO, two right panels) mice. Time-course gene expression profiling was performed on primary cultures challenged with TGF-β (+) versus vehicle alone (−) up to 24 hours. Genes included in the TGF-β signature were significantly up-regulated or down-regulated by TGF-β in WT hepatocytes (second panel) but no fluctuation was observed in KO hepatocytes (two right panels).