Fig. 4.

Clinical relevance of the HCC subtypes defined by the TGF-β signatures. (A) Kaplan-Meier plots and log-rank statistics analysis of overall survival do not reveal significant differences between patients defined by positive and negative TGF-β signatures. (B) Within the TGF-β-positive group (dashed purple line) the subtypes of HCC defined by early (blue line) and late (red line) TGF-β signatures show marked differences in the overall survival of patients. (C) Similar results are obtained by the analysis of patient recurrence. (D) Vascular invasion rate in HCC defined by negative, early, and late TGF-β signatures.