Fig. 5.

Comparative and integrative functional genomic strategy improves the molecular prognostication of liver cancer. (A) Stratification of a cohort of 139 cases of human HCC based on the successive integration of gene expression signatures covering relevant genes with respect to survival (A, bad prognosis versus B, good prognosis), cell origin (HB, hepatoblast versus HC, hepatocyte), c-Met/hepatocyte growth factor (HGF), and Tgfbr2/TGF-β signaling pathways. (B-D) Kaplan-Meier plots and log-rank statistics demonstrate the difference in the overall survival between individuals with distinct subtypes of HCC defined by the successive integration of gene expression signatures.