Table 1.

Adverse effects of asenapine compared with other antipsychotics

Drug	QTc prolongation	Sedation	Weight gain	Diabetes	Extrapyramidal effects	Anti-cholinergic effects	Prolactin elevation
Amisulpride	+	−	+	+	+	−	+++
Aripiprazole	−	−	+/−	−	+	−	−
Asenapine	+	+	+/−	−	+	−	+/−
Chlorpromazine	++	+++	++	++	++	++	++
Clozapine	+	+++	+++	+++	−	+++	−
Haloperidol	+	+	+	+	+++	−	+++
Olanzapine	+	++	+++	+++	+/−	+	+
Quetiapine	++	++	++	++	−	−	−
Risperidone	+	+	++	++	+	+	+++
Sulpiride	+	−	+	+	+	−	+++
Ziprasidone	++	+	+/−	−	+/−	−	+/−

Abbreviations:+++, high incidence/severity; ++, moderate incidence/severity; +, low incidence/severity; −, very low incidence/severity. Adapted from The Maudsley Prescribing Guidelines 10th Edition.⁶¹