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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: Clin Pharmacol Ther. 2008 Aug 6;85(2):164–172. doi: 10.1038/clpt.2008.154

Figure 1.

Figure 1

Schematic representation of the metabolism of mercaptopurine and the enzymes involved. GDP, guanosine diphosphate; GMP, guanosine monophosphate; GMPS, guanosine monophosphate synthase; GTP, guanosine triphosphate; HPRT, hypoxanthine phosphoribosyltransferase; IMPDH, inosine monophosphate dehdrogenase; IDP, inosine diphosphate; IMP, inosine monophosphate; ITP, inosine triphosphate; ITPA, inosine triphosphate pyrophosphatase; K, kinase; TPMT, thiopurine S-methyltransferase; XO, xanthine oxidase.