Figure 2.

Correlation between an output value and the fraction of methylated CpG sites by bisulphite sequencing. Forty samples with variable methylation levels (11 loci in four cell lines) were analysed by bisulphite sequencing, and the fraction of methylated CpG sites among all the CpG sites within 200 bp of the microarray probes was obtained. The numbers of CpG sites in this region ranged from 7 to 21. The Me value had a linear correlation with the fraction (r = 0.88, Pearson's correlation coefficient).