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. 2009 Sep 18;16(5):275–286. doi: 10.1093/dnares/dsp017

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© The Author 2009. Published by Oxford University Press on behalf of Kazusa DNA Research Institute

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Degree of demethylation according to the positions against TSSs, and the lack of association between the degree of demethylation and that of re-expression. (A) Degree of demethylation according to the positions against TSSs. Methylation levels were analysed for CGIs methylated in AGS without 5-aza-dC treatment. 5-Aza-dC treatment induced demethylation of upstream CGIs, gene body CGIs, downstream CGIs, divergent CGIs and promoters to similar degrees. (B) Site Me value of TFAP2C and KISS1R in AGS and AGS treated with 5-aza-dC. In 1400–1800 bp against TSS, the degree of demethylation was high in TFAP2C and low in KISS1R, which representatively showed variation among individual genes. (C) Degree of demethylation of promoters and degree of re-expression in AGS. The degree of demethylation of promoters was not associated with that of re-expression of methylated genes after 5-aza-dC treatment.