Table 3.
Effect of Hepatic Microsomes on the Metabolic Stability of SSRIs, PDE4 Inhibitors and Dual PDE4 inhibitor/SSRIs.
| Comp | RLMa t1/2 (min) |
MLMb t1/2 (min) |
HLMc t1/2 (min) |
|---|---|---|---|
| 14 | 106.3 | 56.0 | NAd |
| 19 | NA | 211.3 | NDe |
| 21 | NA | 153.9 | ND |
| 22 | NA | ND | ND |
| 24 | 129.0 | 58.5 | NA |
a
RLM, rat liver microsomes
b
MLM, mouse liver microsomes
c
HLM, human liver microsomes
d
NA, Not available.
e
ND, No detectable degradation observed in the presence of animal liver microsomes supplemented with NADPH for 60 mins.