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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Leuk Res. 2008 Sep 16;33(4):569–571. doi: 10.1016/j.leukres.2008.07.030

Fig. 1. NUP214-ABL1 gene in T-cell leukemic cells.

Fig. 1

Fig. 1

A: Morphology of leukemic cells. Atypical cells show convoluted nuclear contour, dense chromatin, and bizarre mitotic figures. Cells with “flower shape” nuclei are also observed (arrows).

B: Metaphase spreads. Double minute chromosomes are circled.

C: High copy number amplification of NUP214 and ABL1. The result of SNP-chip analysis (chromosome 9) revealed high copy number amplification of chromosome 9q34 region (arrow head) which contained NUP214 and ABL1 genes (arrows indicate the direction of transcription of the genes).

D: NUP214-ABL1 fusion was detected in T-cell leukemia. Rapid amplification of cDNA ends (RACE) method and nucleotide sequencing showed the fusion of exon 31 of NUP214 and exon 3 of ABL1. Schematic representation of the structure of NUP214-ABL1 fusion protein is shown.