Table 2.

Inhibition constants for saporin-L1 inhibitors^A

Inhibitor	Ki* (nM)
A-14 (9-DA) 2′-OMe	5.6 ± 0.8
A-14 (9-DA) RNA	3.7 ± 0.7
A-14 (9-DA) DNA	3.1 ± 0.5
A-10 (9-DA) 2′-OMe	4.2 ± 1.3
cyclic oxime (9-DA) 2′-OMe	3.9 ± 0.5
cyclic oxime (9-DA) DNA	2.3 ± 0.1
G(9-DA)GA 2′-OMe	8.7 ± 2.3
G(9-DA)Gs3 2′-OMe	7.5 ± 1.6
s3(9-DA)Gs3 2′- OMe	6.4 ± 1.7
s3(9-DA)s3	690 ± 100 B
9-DA	> 0.5 × 106 B

^ASee Figure 1 for structures of inhibitors.

^BValues are K_i with no slow onset observed.