Table 1.
ID # | Age | Gender | Ethnicity | Genotype | Pre-treatment HCV RNA (IU/ml) |
Treatment Weeks | RVR | SVR |
---|---|---|---|---|---|---|---|---|
Incarcerated Cohort | ||||||||
1 | 21 | M | Caucasian | 1a | 363,000 | 22 | yes | yes |
2 | 31 | M | Caucasian | 1a | 22,200 | 24 | yes | yes |
3 | 29 | M | Caucasian | 1a | 93,699 | 25 | yes | yes |
4 | 25 | F | Caucasian | 2b | 1,665,560 | 15 | yes | yes |
5 | 34 | M | Caucasian | 1a | 252,532 | 24 | yes | yes |
6 | 41 | M | Caucasian | 4a | 88,574 | 24 | yes | yes |
7 | 29 | M | Caucasian | 3a | 834,400 | 26 | yes | yes |
8 | 35 | M | Caucasian/Hispanic | 1a | 32,366 | 16 | yes | yes |
9 | 24 | M | Caucasian | 1a | 261,437 | 24 | yes | yes |
10 | 19 | F | Caucasian | 1a | 131,819 | 24 | yes | viral breakthrough |
11 | 32 | M | Caucasian | 1a | 546,478 | 20 | no | viral breakthrough |
12 | 30 | M | Caucasian | 4acd | 1,590 | 16 | yes | lost to follow up |
13 | 24 | F | Caucasian | 3a | 190,778 | 12 | yes | lost to follow up |
14 | 39 | M | Caucasian | 3a | 93,185 | 12 | yes | yes |
15 | 40 | M | Caucasian | 1a | 1,790,000 | 28 | yes | no |
Community Cohort | ||||||||
16 | 63 | F | Caucasian | 1 | 95,800 | 12 | yes | yes |
17 | 36 | M | Caucasian | 1b | 1,230 | 24 | yes | yes |
18 | 20 | F | Caucasian | 1a | 235,000 | 24 | yes | yes |
19 | 26 | F | Caucasian | 1a | 648 | 24 | yes | yes |
20 | 20 | M | Caucasian/Black | 1ab | > 700000 | 48 | no | yes |
21 | 27 | M | Caucasian | 1 | 292,000 | 24 | yes | lost to follow up |
22 | 29 | M | Caucasian | 1 | > 700000 | 48 | yes | yes |
23 | 20 | F | Caucasian | 1 | > 700000 | 24 | yes | yes |
24 | 40 | F | Caucasian | 3a | > 700000 | 12 | yes | yes |
25 | 41 | M | Hispanic | 3a | 1,385 | 24 | yes | yes |
HCV RNA monitoring of patient 1 utilized bDNA Quantiplex, Chiron Corporation for all time points.
A course of 48 weeks of therapy was recommended to patient 15 who delayed treatment for 27 months due to depression; he self-discontinued treatment after 27 weeks with subsequent virologic rebound.
Patient 22 and 25 were HIV seropositive.