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. Author manuscript; available in PMC: 2010 Jun 17.
Published in final edited form as: J Am Chem Soc. 2009 Jun 17;131(23):8083–8091. doi: 10.1021/ja900098y

Figure 7. Different inhibitors cause different rates of exchange of the active site residues of GIVA PLA2.

Figure 7

The number of incorporated deuterons at seven time points in five different regions, 196-201, 225-232, 393-397, 577-591, and 670-682 in GIVA PLA2 are plotted onto the docked models. Areas that show both a greater than 10% change in exchange between oxoamide and pyrrophenone in at least 3 consecutive time points as well as less exchange with the oxoamide compared to the apo structure (left), and more exchange with pyrrophenone compared to the apo structure (right) are shown in color in the respective structures.