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. Author manuscript; available in PMC: 2009 Oct 16.
Published in final edited form as: Nat Rev Neurosci. 2008 Nov 12;9(12):947–957. doi: 10.1038/nrn2513

Figure 2.

Figure 2

Sexual dimorphism in the maturation of white matter during adolescence. Top panel (A) illustrates age-related changes in the relative (brain-size corrected) volume of white matter summed across the frontal, parietal, temporal and occipital lobes. Bottom panel (B) illustrates age-related changes in mean-centered values of magnetization-transfer ratio (MTR) in the lobar white-matter; MTR provides an indirect index of myelination. The plots are based on data obtained by Perrin et al40. Note that the opposite developmental trajectories in the volume and MTR suggest that age-related increases in white matter during male adolescence are not driven by myelination. See the original report for further information about the relationship between white matter and testosterone in male adolescents with different variants of androgen-receptor gene.