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. 2009 Oct 16;106(43):18367–18372. doi: 10.1073/pnas.0907652106

Fig. 5.

Fig. 5.

Age-dependent deficits in working memory in FeCγ25 mice. FeCγ25 mice exhibit age-dependent deficits in working memory (A, C, and E) but not in exploratory behavior (B, D, and F) in the Y maze. The percentage of spontaneous alternations (working memory) for wild-type, Fe27 and FeCγ25 mice at 4 months of age (A), 8 months of age (C), and 8 months of age after a 30-day lithium diet (E). Note that at 8 months of age, FeCγ25 mice showed a small but significantly increased error rate compared to other animals. This deficit was largely abolished when age-matched animals were placed on lithium diet. The average number of arm entries (exploratory behavior) for wild-type, Fe27, and FeCγ25 at 4 months of age (B), 8 months of age (D), and at 8 months of age after a 30-day lithium diet (F). There were no significant differences in any of the groups. The number at the bottom of each bar denotes the number of animals tested in each group. All data expressed as ± SEM, * P < 0.05.