Table 1.

Candidate variables used to predict peak VO₂ and VE/VCO₂ slope

sex diabetes (history of) stroke (history of) hypertension (history of) prior CABG prior valve surgery prior PCI prior MI PAD (history of) COPD (history of) depression (history of) atrial fibrillation or atrial flutter (history of) bi-ventricular pacemaker other pacemaker on an ACE inhibitor at baseline on a beta blocker at baseline etiology of heart failure (ischemic vs. non-ischemic) CPX mode: treadmill or bicycle ergometer heart failure hospitalizations in the last 6 months: 0, 1, 2, or 3+ region: 4 regions of US, Canada, or France race: African American, White, or Other NYHA class (II vs. III/IV) at baseline CCS angina class at baseline rest ECG ventricular conduction (baseline CPX test): normal, LBBB, RBBB, IVCD, or paced rest ECG rhythm (baseline CPX test): sinus rhythm, atrial fib, or other smoking status: never, current, or past diastolic BP systolic BP height weight BMI resting HR: at clinic visit resting HR: at baseline CPX test LVEF (as assessed by the core lab unless not measurable, in which case by site) age

CABG, coronary artery bypass graft surgery; PCI, percutaneous coronary intervention; MI, myocardial infarction; PAD, peripheral arterial disease; COPD, chronic obstructive pulmonary disease; ACE, angiotensin-converting enzyme; CPX, cardiopulmonary exercise testing; NYHA, New York Heart Association; CCS, Canadian Cardiovascular Society; ECG, electrocardiogram; LBBB, left bundle branch block; RBBB, right bundle branch block; IVCD, intraventricular conduction delay; BP, blood pressure; BMI, body mass index; HR, heart rate; LVEF, left ventricular ejection fraction