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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Gene Ther. 2009 Jul 9;16(10):1223–1233. doi: 10.1038/gt.2009.74

Figure 1. Cytotoxicity and replication of Lister strain of vaccinia virus in human cancer cells and normal epithelial cells.

Figure 1

A, Comparison of cytotoxicity of Lister strain vaccinia virus and adenovirus in a panel of human pancreatic cancer cell lines. Mean EC50 values were derived by MTS assay six days after infection of the Lister strain of vaccinia virus and adenovirus, displayed in order of Ad5/VVLister ratio (a value greater than 1.0 indicates that VV Lister was more potent); B and C, The viral replication of vaccinia virus in human pancreatic cancer cells insensitive to adenovirus; D, Viral replication in human squamous epithelial cells. Cells were infected with 1 PFU/cell (5PFU/cell for NHEK) of VVLister and cell lysates harvested over a time course. Mean viral replication values ± SEM were determined by the TCID50 assay.