Table 6.
Genetic and functional alterations in candidate genes among in vitro melanoma cell lines
| Cell line derived from |
ERK1 | ERK2 | pERK | p16 | BRAF | NRAS | p16CDKN2A |
|---|---|---|---|---|---|---|---|
| Primary melanoma | |||||||
| GR-Mel | +++ | ++ | + | ++ | |||
| LCP-Mel | +++ | +++ | ++ | + | V600R | Del exon 2 | |
| MNG | +++ | +++ | ++/+++ | + | |||
| PNP-Mel | +++ | +++ | ++ | + | V600E | G101W | |
| ST-Mel | ++/+++ | +++ | +++ | ++ | G466E | ||
| Metastatic lymph node | |||||||
| CN-Mel | +++ | +++ | ++ | + | Q61R | ||
| CR-Mel | +++ | +++ | ++ | + | Q61K | Del exon 2 | |
| GL-Mel | +++ | +++ | ++ | + | Del exon 2 | ||
| LCM-Mel | +++ | ++ | ++ | - | V600R | Del exons 1-2 | |
| MAR | +++ | +/++ | + | + | |||
| SK-Mel-28 | +++ | ++ | ++ | +++ | V600E | ||
| 13443-Mel | +++ | ++ | + | +++ | |||
| Cutaneous metastasis | |||||||
| LB-24-Mel | +++ | +++ | +++ | ++ | |||
| M14 | +++ | +++ | ++ | + | V600E | 455insCdel26 IVS1+2T>C | |
| PR-Mel | +++ | +++ | + | ++ | V600R | ||
| SN-Mel | ++ | ++/+++ | + | ++ | V600E | ||
| WM-266-4 | +++ | ++ | ++/+++ | - | V600D | Del exon 1 | |
| 397-Mel | ++ | ++ | ++ | + | Del exon 2 |