Table 1.

Promoter methylation of genes in Oral cancer

Gene	Cancer type	Method for methylation analysis	Reference
TSC2	Oral squamous cell carcinoma (OSCC)	COBRA	[44]
CDKN2A, p14ARF	OSCC	MSP	[10]
MGMT	Head & Neck squamous cell carcinoma (HNSCC)	MSP	[3]
RASSF1A	Betal-associated oral carcinoma	MSP	[13]
p16INK4a, p15, MLH1, MGMT, E-CADHERIN	OSCC	Restriction multiplex PCR	[29]
p16INK4a, RASSF1A, DAPK	Salivary adenoid cystic carcinoma	MSP	[30]
MGMT	HNSCC	MSP	[21]
p16INK4a	HNSCC	MSP	[22]
MGMT, p16INK4a, MLH1	HNSCC	MSP	[23]
CNKN2, CDH1, MGMT, DAPK, DBC1, p14, CDKN2B, RARB, RASSF1A, MLH1, p73, DCC, FHIT, SERPINB5	HNSCC &/or OSCC	MSP, PCR-based restriction assay and/or bisulfite sequencing	[11]
p16INK4a, CYCLIN A1, RARB, E-CADHERIN, MGMT, STAT1, ATM, MLH1, TIMP3	SCC of the oral cavity or oropharynx	pryosequencing	[26]
RASSF2	OSCC	MSP	[45]
RECK	OSCC	MSP	[46]
ATM	HNSCC	MSP	[47]
p16INK4a, CYTOGLOBIN, CYCLIN A1	OSCC	pyrosequencing	[35]
MLH1	HNSCC	MSP	[15]
p16INK4a, MGMT, DAPK, E-CADHERIN	Laryngeal and hypopharyngeal cancer	MSP	[24]
CYTOGLOBIN	Oral or oropharyngeal squamous cell carcinoma	pyrosequencing	[48]
RIZ1	Nasopharyngeal carcinoma	MSP	[49]
CDKN2A	OSCC		[50]
p16INK4a, p14ARF, MGMT, RB1, PTEN, p27KIP1	OSCC	MSP	[51]
APC	OSCC	MSP	[52]
CDH1	HNSCC	MSP	[53]
p16INK4a, DAPK, E-CADHERIN, RASSF1A	HNSCC	MSP	[54]
TIMP3, CDH1	HNSCC	MSP	[55]
p16INK4a	Oral epithelial dysplasia	MSP	[56]
RARB, MGMT, RASSF1, E-CADHERIN	Salivary gland carcinoma	pyrosequencing	[57]
MGMT, p16INK4a	OSCC	MSP	[31]
RASSF1A, RASSF2A, HIN-1	OSCC	PCR-denaturing HPLC	[12]
MLH1, MSH2	OSCC	MSP	[58]
RUNX3	OSCC	MSP	[59]
LINE-1	OSCC	COBRALINE-1	[60]
SFRP1, SFRP2, SFRP5	OSCC	MSP	[61]
miR-137	OSCC	COBRA and bisulfite sequencing	[62]