Table 4.

Multivariate Cox models for the association between gene methylation and cancer survival/cancer recurrence

		Hazard Ratio
	MGMT	CDKN2A	RASSF1
Overall Survival
Unmethylated	1 (reference)	1 (reference)	1 (reference)
Methylated	2.17 (1.11-4.23)A	1.41 (0.35-5.75)C	0.88 (0.20-3.84)C
< 6.9% Methylated	1.52 (0.59-3.91)B	not evaluated	not evaluated
≥ 6.9% Methylated	4.38 (1.78-10.76)B	not evaluated	not evaluated
Test of trend	p = 0.002	---	---
Disease-Free Survival
Unmethylated	1 (reference)	1 (reference)	1 (reference)
Methylated	3.49 (1.62-7.52)D	2.57 (0.47-14.12)C	2.54 (0.82-7.93)C
< 6.9% Methylated	3.03 (1.24-7.44)B	not evaluated	not evaluated
≥ 6.9% Methylated	5.46 (1.75-17.00)B	not evaluated	not evaluated
Test of trend	p = 0.001	---	---

^A Adjusted for age, smoking, alcohol use, and stage at diagnosis

^B Adjusted for age, gender, alcohol use, and stage at diagnosis

^C Adjusted for age, alcohol use, and stage at diagnosis

^D Adjusted for age, smoking, alcohol use, treatment, and stage at diagnosis