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Biosynthetic hypothesis for conversion of the thiopeptide framework into NOS. Color coding indicates the posttranslational modifications on the peptide precursor NosM (orange), attachment of the indolic acid moiety to the macrocyclic core (purple), and tailoring steps including hydroxylations on Glu43 at the γ-position and central pyridine domain at the C-5 position, and final cleavage of an acrylic acid to afford NOS (blue).
