Table 1.
1H-NMR data of jaspamide Q (2), and R (3), (500 MHz, CDCl3-d).
| Position | Jaspamide Q (2) |
Jaspamide R (3) |
|---|---|---|
| δH mult. (J Hz) | δH mult. (J Hz) | |
| 2 | 2.51 (1H, m) | 2.49 (1H, m) |
| 3 | A) 2.37 (1H, dd, 11.5, 15.8 Hz) | A) 2.37 (1H, dd, 11.5, 15.8 Hz) |
| B) 1.90 (1H, d, 15.8 Hz) | B) 1.90 (1H. d, 15.8 Hz) | |
| 5 | 4.79 (1H, d, 6.7 Hz) | 4.74 (1H, d, 6.7 Hz) |
| 6 | 2.23 (1H, m) | 2.23 (1H, m) |
| 7 | A) 1.32 (1H, m), B) 1.10 (1H, m) | A) 1.32 (1H, m), B) 1.10 (1H, m) |
| 8 | 4.64 (1H, m) | 4.60 (1H, m) |
| 10 | A) 2.67 (1H, dd, 4.7, 15.0 Hz) | A) 2.67 (1H, dd, 4.7, 15.0 Hz) |
| B) 2.61 (1H, dd, 5.7, 14.8 Hz) | B) 2.61 (1H, dd, 5.7, 14.8 Hz) | |
| 11 | 5.25 (1H, dd, 5.3, 8.6 Hz) | 5.25 (1H, dd, 5.3, 8.6 Hz) |
| 13 | 5.63 (1H, dd, 6.3, 10.0 Hz) | 5.73 (1H, dd, 6.3, 10.0 Hz) |
| 15 | 4.77 (1H, m) | 4.72 (1H, m) |
| 16 | 1.04 (3H, d, 6.6 Hz) | 0.81 (3H, d, 6.7 Hz) |
| 17 | 2.97 (3H, s) | 2.98 (3H, s) |
| 18 | A) 3.43 (1H, dd, 6.3, 15.5 Hz) | A) 3.33 (1H, dd, 6.3, 15.5 Hz) |
| B) 3.17 (1H, dd, 10.4, 15.2 Hz) | B) 3.18 (1H, dd, 10.4, 15.2 Hz) | |
| 21 | 7.61 (1H, d, 8.0 Hz) | 7.41 (1H, br s) |
| 22 | 7.11 (1H, t, 8.0 Hz) | |
| 23 | 7.18 (1H, t, 8.0 Hz) | 7.20 (1H, d, 8.2 Hz) |
| 24 | 7.35 (1H, d, 8.0 Hz) | 7.42 (1H, d, 8.2 Hz) |
| 26 | 6.87 (1H, br s) | |
| 28 | 6.90 (1H, d, 8.3 Hz) | 6.98 (1H, d, 8.4 Hz) |
| 29 | 6.69 (1H, d, 8.3 Hz) | 6.71 (1H, d, 8.4 Hz) |
| 31 | 6.69 (1H, d, 8.3 Hz) | 6.71 (1H, d, 8.4 Hz) |
| 32 | 6.90 (1H, d, 8.3 Hz) | 6.98 (1H, d, 8.4 Hz) |
| 33 | 1.06 (3H, d, 6.3 Hz) | 1.05 (3H, d, 6.1 Hz) |
| 34 | 0.83 (3H, d, 6.5 Hz) | 0.81 (3H, d, 6.7 Hz) |
| 35 | 1.59 (3H, s) | 1.57 (3H, s) |
| 36 | 1.15 (3H, d, 6.8 Hz) | 1.13 (3H, d, 6.8 Hz) |
| NH-Tyr | 7.46 (1H, d, 8.6 Hz) | 7.53 (1H, d, 8.6 Hz) |
| NH-Trp | 8.24 (1H, br s) | 8.42 (1H, br s) |
| NH-Ala | 6.73 (1H, d, 6.4 Hz) | 6.65 (1H, d, 6.5 Hz) |