Table 4.
Association of leukocyte count, other inflammatory markers, and other variables with platelet aggregation to collagen before and after aspirin.
| Variable | Before Aspirin Beta ± SE (P-value) |
After Aspirin Beta ± SE (P-value) |
||
|---|---|---|---|---|
| univariable | multivariable | univariable | multivariable | |
| Total leukocyte count (×103 cells/μL) | 1.0372 ± 0.0703 (<0.0001) | 1.0744 ± 0.0859 (<0.0001) | 0.0484 ± 0.0094 (<0.0001) | 0.0513 ± 0.0098 (<0.0001) |
| Age (years) | −0.0108 ±0.0108 (0.3173) | 0.0121 ± 0.0127 (0.3415) | 0.0040 ± 0.0016 (0.0103) | 0.0078 ± 0.0019 (0.0001) |
| Male sex | −0.9358 ±0.2458 (0.0002) | 0.7459 ± 0.3642 (0.0411) | −0.1536 ±0.0398 (0.0001) | −0.0596 ±0.0529 (0.2606) |
| African American race | −0.2971 ±0.3250 (0.3610) | −0.5010 ±0.3701 (0.1766) | 0.1225 ± 0.0452 (0.0070) | 0.0635 ± 0.0472 (0.1789) |
| Hypertension | 0.2730 ± 0.2950 (0.3551) | 0.1091 ± 0.3407 (0.7489) | 0.0580 ± 0.0382 (0.1299) | −0.0340 ±0.0481 (0.4804) |
| Diabetes | −0.2614 ±0.5340 (0.6247) | −0.5975 ±0.5179 (0.2492) | 0.0590 ± 0.0612 (0.3362) | −0.0041 ±0.0675 (0.9514) |
| Current smoking | 0.7441 ± 0.3296 (0.0244) | −0.0451 ±0.3621 (0.9009) | 0.0842 ± 0.0409 (0.0402) | 0.0562 ± 0.0424 (0.1857) |
| Total cholesterol (mg/dl) | −0.0002 ±0.0035 (0.9531) | −0.0048 ±0.0034 (0.1602) | 0.0007 ± 0.0005 (0.1703) | −0.00004 ± 0.0005 (0.9267) |
| Body mass index (kg/m2) | 0.0847 ± 0.0222 (0.0001) | 0.0450 ± 0.0264 (0.0885) | 0.0065 ± 0.0026 (0.0131) | 0.0002 ±0.0033 (0.9642) |
| C-reactive protein (mg/L*) | 0.5226 ± 0.0943 (<0.0001) | 0.1957 ± 0.1186 (0.0995) | 0.0209 ± 0.0129 (0.1072) | −0.0049± 0.0163 (0.7636) |
| Interleukin-6 (ng/L*) | 0.2941 ± 0.1323 (0.0268) | −0.2166 ±0.1305 (0.0978) | 0.0237±0.0183 (0.1973) | −0.0382 ±0.0189 (0.0432) |
| Fibrinogen (mg/dl) | 0.0027 ± 0.0012 (0.0231) | −0.0038 ±0.0014 (0.0066) | 0.0006 ± 0.0002 (0.0006) | 0.0001± 0.0002 (0.6339) |
| Hematocrit (%) | −0.1675 ±0.0323 (<0.0001) | −0.2754 ±0.0434 (<0.0001) | −0.0268 ±0.0048 (<0.0001) | −0.0192 ±0.0065 (0.0034) |
| Platelet count (×103 cells/μL) | 0.0194±0.0021 (<0.0001) | 0.0096 ±0.0028 (0.0007) | 0.0002 ±0.0003 (0.5932) | 0.0006 ±0.0004 (0.1322) |
| Mean platelet volume (fl) | −0.0677 ±0.1833 (0.7122) | −0.0176 ±0.2110 (0.9336) | 0.1224 ± 0.0238 (<0.0001) | 0.1217 ± 0.0279 (<0.0001) |
| Thromboxane-B2 (ng/108 platelets*) | 0.7423 ± 0.1806 (<0.0001) | 0.9911 ± 0.2281 (<0.0001) | 0.1381 ± 0.0177 (<0.0001) | 0.1430 ± 0.0195 (<0.0001) |
Values in bold type denote significance in both univariable (unadjusted) and multivariable (adjusted for all variables) linear regression models.
*
Transformed variable