Table 5.
Association of leukocyte count, other inflammatory markers, and other variables with platelet aggregation to ADP before and after aspirin
| Variable | Before Aspirin Beta ± SE (P-value) |
After Aspirin Beta ± SE (P-value) |
||
|---|---|---|---|---|
| univariable | multivariable | univariable | multivariable | |
| Total leukocyte count (×103 cells/μL) | 0.7071 ± 0.0839 (<0.0001) | 0.5785 ± 0.0905 (<0.0001) | 0.8380 ± 0.0883 (<0.0001) | 0.6285 ± 0.1038 (<0.0001) |
| Age (years) | 0.0105 ± 0.0111 (0.3440) | 0.0264 ± 0.0129 (0.0417) | 0.0133 ± 0.0120 (0.2681) | 0.0309 ± 0.0132 (0.0195) |
| Male sex | −3.6425 ±0.2903 (<0.0001) | −1.1800 ±0.4194 (0.0051) | −3.6593 ±0.2888 (<0.0001) | −1.2605 ±0.4294 (0.0035) |
| African American race | 1.3570 ± 0.3348 (0.0001) | 0.4583 ± 0.3570 (0.1999) | 1.9451 ± 0.3785 (<0.0001) | 1.3101 ± 0.3736 (0.0005) |
| Hypertension | 0.4078 ± 0.3005 (0.1754) | −0.2383 ±0.3114 (0.4444) | 0.6339 ± 0.3368 (0.0605) | −0.2267± 0.3599 (0.8563) |
| Diabetes | 0.0445 ± 0.5544 (0.9361) | −0.6983 ±0.5286 (0.1871) | 0.2745 ± 0.6116 (0.6538) | −1.0585 ±0.5432 (0.0519) |
| Current smoking | 0.2522 ± 0.3657 (0.4908) | 0.0292 ±0.3840 (0.9395) | 0.2181 ± 0.3871 (0.5734) | −0.1366 ±0.3830 (0.7216) |
| Total cholesterol (mg/dl) | 0.0019 ± 0.0037 (0.6075) | −0.0048 ±0.0032 (0.1420) | 0.0095 ± 0.0043 (0.0268) | 0.0024 ± 0.0039 (0.5366) |
| Body mass index (kg/m2) | 0.0759 ± 0.0201 (0.0002) | 0.0041 ± 0.0212 (0.8487) | 0.1226 ± 0.0247 (<0.0001) | 0.0272 ± 0.0255 (0.2864) |
| C-reactive protein (mg/L*) | 0.4005 ± 0.1012 (0.0001) | −0.3015 ±0.1114 (0.0071) | 0.5960 ± 0.1000 (<0.0001) | −0.0895 ±0.1303 (0.4928) |
| Interleukin-6 (ng/L*) | 0.4531 ± 0.1453 (0.0019) | −0.1379 ±0.1320 (0.2968) | 0.6048 ± 0.1478 (0.0001) | −0.0563± 0.1359 (0.6787) |
| Fibrinogen (mg/dl) | 0.0083 ± 0.0013 (<0.0001) | 0.0014 ± 0.0015 (0.3579) | 0.0087 ± 0.0014 (<0.0001) | −0.0016± 0.0017 (0.3460) |
| Hematocrit (%) | −0.4367 ±0.0355 (<0.0001) | −0.2366 ±0.0551 (<0.0001) | −0.3830 ±0.0331 (<0.0001) | −0.1450 ±0.0500 (0.0039) |
| Platelet count (×103 cells/μL) | 0.0334 ±0.0022 (<0.0001) | 0.0326 ±0.0026 (<0.0001) | 0.0351 ±0.0026 (<0.0001) | 0.0357 ±0.0031 (<0.0001) |
| Mean platelet volume (fl) | 1.0665 ± 0.1970 (<0.0001) | 1.8617 ± 0.2070 (<0.0001) | 1.6325 ± 0.1893 (<0.0001) | 2.3377 ± 0.1822 (<0.0001) |
| Thromboxane-B2 (ng/108 platelets*) | 0.0070 ± 0.1457 (0.9618) | −0.1576 ±0.1699 (0.3541) | −0.3591 ±0.1208 (0.0031) | −0.2250 ±0.1098 (0.0410) |
Values in bold type denote significance in both univariable (unadjusted) and multivariable (adjusted for all variables) linear regression models.
*
Transformed variable