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. Author manuscript; available in PMC: 2010 Jul 10.
Published in final edited form as: J Mol Biol. 2009 May 13;390(2):319–338. doi: 10.1016/j.jmb.2009.05.005

Fig. 10.

Fig. 10

Model for PKR activation by dimer RNA hairpin. Monomer RNA hairpin (~23 bp) binds PKR monomer and PKR is inhibited. In contrast, dimer RNA (~46 bp), which is double the number of monomer base pairs, binds PKR dimer and PKR is activated. Not shown are the two dsRBMs in the dsRBD, both of which contact TAR monomer.