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. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: Cancer Res. 2009 Oct 13;69(20):7969–7977. doi: 10.1158/0008-5472.CAN-09-0781

Figure 6. TGFβ induces hypopigmentation, inhibits dendrite formation and increases cell motility.

Figure 6

A) Cell pellets of B16F2 cells treated with H89 αMSH or TGFβ for 48 hours are shown. Numbers indicate digital analysis of pellet darkness. B) NIRVE (white - collected between 410-530nm following illumination at 790nm) and F-actin (red) merged images of B16F2 and 4599 mouse melanoma cells treated with αMSH for 24hrs and, where indicated TGFβ1 or TGFβ2 for 24 hours prior to α-MSH treatment are shown. Scale bar is 50μm. C) i) B16F2 cells plated on deformable collagen/matrigel matrix (cyan) and stained for F-actin (green) and DNA (red). Scale bar is 50μm. ii) Box plots of cell speeds in microns/hour taken from phase contrast movies of B16F2 cells plated on deformable collagen/matrigel matrix over 16 hour period.*indicates p<0.01 Mann-Whitney test.