a Sections of CWD and sheep scrapie stained with LCP(-). b Ratio plots of the ratio 532 nm/Emax vs. the ratio of 532/639 nm distinguishing CWD, BSE and sheep scrapie. c Spectras of LCP(-) (PTAA), native PrP, and recombinant PrP. Fibrillation of preparation A are started from natively folded recPrP, and fibrillation of preparation B are started from denatured recPrP. Reprinted by permission from Macmillan Publishers Ltd: Nature Methods [84], ©(2007)