Table 1.

Contributing Issues in Cancer-Related Fatigue

Symptom burden

Pain

Anxiety

Depression

Sleep dysfunction

Obstructive sleep apnea

Restless leg syndrome

Narcolepsy

Insomnia

Nutritional imbalances

Weight changes

Changes in caloric intake

Fluid and electrolyte imbalances

Motility disorders

Physical function changes

Decreased physical activity

Decreased physical conditioning

Medical issues

Anemia (from various etiologies)

Other comorbidities

Infection

Cardiac dysfunction

Connective tissue diseases

Pulmonary dysfunction

Renal dysfunction

Hepatic dysfunction

Neurologic dysfunction

Endocrine dysfunction

Hypothyroidism

Hypogonadism

Diabetes mellitus

Adrenal insufficiency

Medications

Sedating agents (hypnotics, narcotics, neuropathic agents, etc.)

Beta-blockers

Supplements (homeopathic agents)

Other (drug interactions and other medication side effects)

Cancer treatment effects

Chemotherapy

Radiation therapy

Surgery

Bone marrow transplantation

Biologic response modifiers

Hormonal treatment