FIGURE 2.
The CB2R decreases lung injury during sepsis. WT (n = 6) and CB2R-KO mice (n = 6) underwent CLP. A, H&E-stained lung sections of CB2R-KO or WT mice 24 h after a sham- or CLP-operation. B, Lung BAL bacterial load was determined 24 h following CLP. The sample size equals seven per group. C, Representative FACS plot and D, Enumeration of neutrophils (P2 gate) and macrophages (P3 gate) isolated from the BAL of septic mice. E, Lung permeability as determined by protein recovered in the BAL. The sample size equals 10–11 per group. Data expressed as mean ± SEM. *, p < 0.05 as compared with WT.