Table 1.

Physiological parameters

Parameter	Young	Old
Body weight (g)	311 ± 4	571 ± 15*
Tibial length (cm)	4.01 ± 0.09	4.27 ± 0.03
Body weight/tibial length (g/cm)	69.1 ± 2.1	131.9 ± 2.7*
Systolic blood pressure (mm Hg)	139 ± 3	153 ± 1
Diastolic blood pressure (mm Hg)	83 ± 6	87 ± 6
Heart rate (beats/min)	367 ± 13	353 ± 10
Proteinuria (mg/24 h)	14.6 ± 1.2	14.3 ± 0.9
FE Na+ (%)	0.38 ± 0.08	0.31 ± 0.03
Creatinine clearance (ml/min)	2.42 ± 0.42	2.99 ± 0.19

^*p < 0.05 compared with young rats.