Table 2. Association between SNPs from fourteen loci and type 2 diabetes in the Chinese.
| Gene | SNP | Chromosome | Chromosome position (Build 36) | Major/Minor Allele | Risk Allele | Risk allele frequency | OR (95%CI) | P allele | P genotype | Empirical P | |
| Case | Control | ||||||||||
| PPARG | rs1801282 | 3 | 12368125 | C∶G | C | 0.950 | 0.939 | 1.246 (1.017–1.526) | 0.0335 | 0.0701 | 0.4589 |
| KCNJ11 | rs5219 | 11 | 17366148 | C∶T | T | 0.425 | 0.394 | 1.138 (1.034–1.251) | 0.0079 | 0.0031 | 0.1367 |
| WFS1 | rs10010131 | 4 | 6343816 | G∶A | G | 0.955 | 0.946 | 1.213 (0.975–1.510) | 0.0824 | 0.0969 | 0.7816 |
| CDKAL1 | rs10946398 | 6 | 20769013 | A∶C | C | 0.441 | 0.414 | 1.114 (1.014–1.224) | 0.0241 | 0.0074 | 0.3551 |
| CDKAL1 | rs7754840 | 6 | 20769229 | G∶C | C | 0.440 | 0.411 | 1.127 (1.027–1.238) | 0.0119 | 0.0025 | 0.1967 |
| CDKAL1 | rs9460546 | 6 | 20771611 | T∶G | G | 0.444 | 0.411 | 1.145 (1.041–1.260) | 0.0054 | 0.0014 | 0.0944 |
| CDKAL1 | rs7756992 | 6 | 20787688 | G∶A | G | 0.548 | 0.511 | 1.158 (1.056–1.272) | 0.0020 | 0.0010 | 0.0364 |
| CDKAL1 | rs9465871 | 6 | 20825234 | C∶T | C | 0.554 | 0.522 | 1.140 (1.039–1.251) | 0.0057 | 0.0021 | 0.1001 |
| CDKN2A-CDKN2B | rs564398 | 9 | 22019547 | A∶G | G | 0.120 | 0.118 | 1.020 (0.885–1.177) | 0.7826 | 0.2922 | 1 |
| CDKN2A-CDKN2B | rs10811161 | 9 | 19269853 | T∶C | T | 0.604 | 0.520 | 1.406 (1.280–1.546) | 1.37E-12 | 1.13E-13 | 0.0001 |
| IDE-KIF11-HHEX | rs10509645 | 10 | 94267846 | A∶C | C | 0.354 | 0.321 | 1.160 (1.052–1.280) | 0.0031 | 0.0018 | 0.0561 |
| IDE-KIF11-HHEX | rs1111875 | 10 | 94452862 | A∶G | G | 0.310 | 0.273 | 1.201 (1.085–1.330) | 0.0004 | 5.25E-05 | 0.0086 |
| IDE-KIF11-HHEX | rs10748582 | 10 | 94467199 | A∶T | T | 0.238 | 0.196 | 1.282 (1.146–1.435) | 1.46E-5 | 1.51E-05 | 0.0005 |
| IGF2BP2 | rs7651090 | 3 | 186996086 | A∶G | G | 0.282 | 0.246 | 1.200 (1.079–1.334) | 0.0008 | 0.0013 | 0.0141 |
| SLC30A8 | rs13266634 | 8 | 118253964 | C∶T | C | 0.613 | 0.559 | 1.251 (1.138–1.374) | 3.12E-6 | 1.60E-06 | 0.0002 |
| FTO | rs8050136 | 16 | 52373776 | C∶A | A | 0.130 | 0.118 | 1.125 (0.978–1.294) | 0.0996 | 0.1456 | 0.8414 |
| JAZF1 | rs864754 | 7 | 25918763 | T∶A | T | 0.759 | 0.751 | 1.046 (0.934–1.171) | 0.4364 | 0.4359 | 0.9998 |
| TSPAN8-LGR5 | rs7961581 | 12 | 69949369 | T∶C | C | 0.231 | 0.217 | 1.082 (0.965–1.212) | 0.1779 | 0.4068 | 0.9710 |
| THADA | rs7578597 | 2 | 43586327 | T∶C | T | 0.994 | 0.994 | 1.013 (0.548–1.873) | 0.9661 | 0.7604 | 1 |
| ADAMTS9 | rs4607103 | 3 | 64686944 | C∶T | C | 0.635 | 0.629 | 1.030 (0.934–1.137) | 0.5510 | 0.8632 | 1 |
| NOTCH2-ADAM30 | rs2641348 | 1 | 120239407 | T∶C | C | 0.028 | 0.026 | 1.071 (0.801–1.433) | 0.6443 | 0.9776 | 1 |
The OR with 95% CI shown is for the risk allele. P allele is the P value for comparison of the allele distribution between the cases and controls. P genotype is the P value for comparison of genotype distribution between the cases and controls after adjusting age, gender and BMI as confounding factors. Empirical P values were calculated through 10,000 permutations for the difference of allele distribution between cases and controls.