Table 1.
Sociodemographic characteristics and estrogen exposure related variables for cases and controls
| Cases n (%) | Controls n (%) | Age adjusted OR (95%CI) | |
|---|---|---|---|
| Age | |||
| <55 | 103 (22) | 85 (18) | |
| 55–64 | 205 (44) | 159 (34) | |
| 65–74 | 108 (23) | 127 (27) | |
| ≥75 | 53 (11) | 96 (21) | |
| Race | |||
| White | 399(85) | 408(87) | 1 (ref) |
| Black | 38(8) | 23(5) | 1.6 (1.0 – 2.8) |
| Hispanic | 23(5) | 23(5) | 0.9 (0.5 – 1.7) |
| Other | 9(2) | 13(3) | 0.6 (0.3 – 1.4) |
| Educational level | |||
| High school | 169(36) | 155(33) | 1 (ref) |
| College | 207(44) | 193(41) | 0.9 (0.7 – 1.2) |
| Graduate school | 93(20) | 119(26) | 0.6 (0.5 – 0.9) |
| Smoking | |||
| Never | 263(56) | 238(51) | 1 (ref) |
| Former | 173(37) | 178(38) | 0.9 (0.7 – 1.2) |
| Current | 33(7) | 51(11) | 0.5 (0.3 – 0.8) |
| BMI | |||
| <25 | 118(25) | 212(45) | 1 (ref) |
| 25–<30 | 127(27) | 152(33) | 1.6 (1.1 – 2.2) |
| 30–<35 | 80(17) | 71(15) | 2.0 (1.4 – 3.0) |
| ≥35 | 142(30) | 32(7) | 7.6 (4.8 – 11.8) |
| Early menarche (<12 years) | |||
| No | 202(43) | 232(50) | 1 (ref) |
| Yes | 267(57) | 235(50) | 1.2 (1.0 – 1.6) |
| Parity | |||
| 0–1 | 171(37) | 114(24) | 1 (ref) |
| 2 | 157(34) | 167(36) | 0.6 (0.5 – 0.9) |
| ≥3 | 141(30) | 186(40) | 0.6 (0.4 – 0.8) |
| Menopausal status at index date | |||
| Premenopausal | 78(17) | 66(14) | 0.9 (0.6 –1.5) |
| Early menopause (<50) | 122(26) | 142(30) | 1 (ref) |
| Late menopause(≥50) | 216(46) | 199(43) | 1.3 (1.0 – 1.8) |
| Post menopause, age unknown | 53(11) | 59(13) | 1.1 (0.7 – 1.7) |
| Oral contraceptive use | |||
| No | 268(57) | 241(52) | 1 (ref) |
| Yes | 201(43) | 226(48) | 0.7 (0.5 – 0.9) |
| Hormone replacement therapy use | |||
| Never | 376(80) | 345(74) | 1 (ref) |
| Unopposed estrogen replacement therapy only | 37(8) | 39(8) | 0.9 (0.5 – 1.4) |
| Ever combined replacement therapy | 56(12) | 83(18) | 0.6 (0.4 – 0.8) |
| Family history of endometrial cancer | |||
| No | 444(95) | 451(97) | 1 (ref) |
| Yes | 25(5) | 16(3) | 1.6 (0.9 – 3.1) |